ISSN 1662-4009 (online)

ey0017.9-9 | Premature Aging, Cardiometabolic Fitness and Cardiovascular Damage | ESPEYB17

9.9. Advanced glycation end products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation

F Felicetti , AS Cento , P Fornengo , M Cassader , R Mastrocola , F D’Ascenzo , F Settanni , A Benso , E Arvat , M Collino , F Fagioli , M Aragno , E Brignardello

To read the full abstract: Pediatr Blood Cancer. 2020 Mar;67(3):e28106. ebrignardello@cittadellasalute.to.itPremature aging has been proposed as a paradigm to explain the early cardiovascular disease (CVD) that affects young-adult childhood cancer survivors (CCS). Protein glycation is recognized as one of the main factors contributing to aging. Advanced glycation end products (AGEs) are a...

ey0015.2-18 | Dietary composition, age, and sex determine the central inflammatory response associated with the long-term outcomes of excess weight gain | ESPEYB15

Dietary composition, age, and sex determine the central inflammatory response associated with the long-term outcomes of excess weight gain

P Argente-Arizón , F Díaz , P Ros , V Barrios , M Tena-Sempere , LM García-Segura , J Argente , JA Chowen

To read the full abstract: Endocrinology. 2018 Jan 1;159(1):368-387Hypothalamic inflammation has been linked to the development and progression of obesity and its sequelae. Obesity in rodents and humans is associated with gliosis of the arcuate nucleus, a key hypothalamic region for the regulation of energy homeostasis and adiposity. Gliosis, the activation of astrocyte and microglial cell popula...